p58(IPK) suppresses NLRP3 inflammasome activation and IL-1β production via inhibition of PKR in macrophages

The NLRP3 inflammasome activation is a key signaling event for activation and secretion of pro-inflammatory cytokines such as IL-1β from macrophages. p58(IPK) is a molecular chaperone that regulates protein homeostasis through inhibiting eIF-2α kinases including double-stranded RNA–dependent protein...

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Detalles Bibliográficos
Autores principales: Boriushkin, Evgenii, Wang, Joshua J., Li, Junhua, Bhatta, Maulasri, Zhang, Sarah X.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845006/
https://www.ncbi.nlm.nih.gov/pubmed/27113095
http://dx.doi.org/10.1038/srep25013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845006/
https://www.ncbi.nlm.nih.gov/pubmed/27113095
http://dx.doi.org/10.1038/srep25013

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