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Structural correlates of affinity in fetal versus adult endplate nicotinic receptors

Adult-type nicotinic acetylcholine receptors (AChRs) mediate signalling at mature neuromuscular junctions and fetal-type AChRs are necessary for proper synapse development. Each AChR has two neurotransmitter binding sites located at the interface of a principal and a complementary subunit. Although...

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Detalles Bibliográficos
Autores principales: Nayak, Tapan Kumar, Chakraborty, Srirupa, Zheng, Wenjun, Auerbach, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845029/
https://www.ncbi.nlm.nih.gov/pubmed/27101778
http://dx.doi.org/10.1038/ncomms11352