Cargando…

Myristoylated Alanine‐Rich Protein Kinase Substrate (MARCKS) Regulates Small GTPase Rac1 and Cdc42 Activity and Is a Critical Mediator of Vascular Smooth Muscle Cell Migration in Intimal Hyperplasia Formation

BACKGROUND: Transcription of the myristoylated alanine‐rich C kinase substrate (MARCKS) is upregulated in animal models of intimal hyperplasia. MARCKS knockdown inhibits vascular smooth muscle cell (VSMC) migration in vitro; however, the mechanism is as yet unknown. We sought to elucidate the mechan...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yu, Dan, Makkar, George, Strickland, Dudley K., Blanpied, Thomas A., Stumpo, Deborah J., Blackshear, Perry J., Sarkar, Rajabrata, Monahan, Thomas S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2015
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845127/ https://www.ncbi.nlm.nih.gov/pubmed/26450120 http://dx.doi.org/10.1161/JAHA.115.002255

Ejemplares similares

MARCKS Signaling Differentially Regulates Vascular Smooth Muscle and Endothelial Cell Proliferation through a KIS-, p27(kip1)- Dependent Mechanism
por: Yu, Dan, et al.
Publicado: (2015)

Fibroblast Migration Is Regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Protein
por: Ott, Laura E., et al.
Publicado: (2013)

Pathophysiological roles of myristoylated alanine-rich C-kinase substrate (MARCKS) in hematological malignancies
por: Iyer, Deepak Narayanan, et al.
Publicado: (2021)

X MARCKS the spot: myristoylated alanine-rich C kinase substrate in neuronal function and disease
por: Brudvig, Jon J., et al.
Publicado: (2015)

Myristoylated, alanine-rich C-kinase substrate (MARCKS) regulates toll-like receptor 4 signaling in macrophages
por: Issara-Amphorn, Jiraphorn, et al.
Publicado: (2023)

Myristoylated, Alanine-rich C-kinase Substrate (MARCKS) regulates Toll-like receptor 4 signaling in macrophages
por: Issara-Amphorn, Jiraphorn, et al.
Publicado: (2023)

MARCKS regulates neuritogenesis and interacts with a CDC42 signaling network
por: Brudvig, J. J., et al.
Publicado: (2018)

Stimulation of Fascin Spikes by Thrombospondin-1 Is Mediated by the Gtpases Rac and Cdc42
por: Adams, Josephine Clare, et al.
Publicado: (2000)

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury
por: Blattner, Simone M., et al.
Publicado: (2013)

A myristoylated alanine-rich C-kinase substrate (MARCKS) inhibitor peptide attenuates neutrophil outside-in β(2)-integrin activation and signaling
por: Conley, Haleigh, et al.
Publicado: (2023)

Evidence for a Novel Mechanism of the PAK1 Interaction with the Rho-GTPases Cdc42 and Rac
por: Shin, Yong Jae, et al.
Publicado: (2013)

Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases
por: Oprea, Tudor I., et al.
Publicado: (2015)

Equine Alphaherpesviruses Require Activation of the Small GTPases Rac1 and Cdc42 for Intracellular Transport
por: Kolyvushko, Oleksandr, et al.
Publicado: (2020)

The role of Rho GTPases’ substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study
por: Liu, Yuan, et al.
Publicado: (2020)

Small GTPase Rin induces neurite outgrowth through Rac/Cdc42 and calmodulin in PC12 cells
por: Hoshino, Mitsunobu, et al.
Publicado: (2003)

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy
por: Yang, Penghua, et al.
Publicado: (2019)

Desmoglein 3 acting as an upstream regulator of Rho GTPases, Rac-1/Cdc42 in the regulation of actin organisation and dynamics
por: Man Tsang, Siu, et al.
Publicado: (2012)

The evolutionary history of effectors downstream of Cdc42 and Rac
por: Cotteret, Sophie, et al.
Publicado: (2002)

Targeting Rac and Cdc42 GEFs in Metastatic Cancer
por: Maldonado, Maria del Mar, et al.
Publicado: (2020)

Optogenetic dissection of Rac1 and Cdc42 gradient shaping
por: de Beco, S., et al.
Publicado: (2018)

MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging
por: Muthusamy, Nagendran, et al.
Publicado: (2015)

CdGAP/ARHGAP31, a Cdc42/Rac1 GTPase regulator, is critical for vascular development and VEGF-mediated angiogenesis
por: Caron, Christine, et al.
Publicado: (2016)

Phosphoinositide 3-kinase enables phagocytosis of large particles by terminating actin assembly through Rac/Cdc42 GTPase-activating proteins
por: Schlam, Daniel, et al.
Publicado: (2015)

Leucine-rich repeat kinase-1 regulates osteoclast function by modulating RAC1/Cdc42 Small GTPase phosphorylation and activation
por: Zeng, Canjun, et al.
Publicado: (2016)

Functional Characterization and Cellular Dynamics of the CDC-42 – RAC – CDC-24 Module in Neurospora crassa
por: Araujo-Palomares, Cynthia L., et al.
Publicado: (2011)

Distinct predictive performance of Rac1 and Cdc42 in cell migration
por: Yamao, Masataka, et al.
Publicado: (2015)

MARCKS and MARCKS-like proteins in development and regeneration
por: El Amri, Mohamed, et al.
Publicado: (2018)

Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis
por: Duan, Xin, et al.
Publicado: (2021)

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes
por: Cox, Dianne, et al.
Publicado: (1997)

Imaging Dynamic Molecular Signaling by the Cdc42 GTPase within the Developing CNS
por: Sharifai, Nima, et al.
Publicado: (2014)

Phosphatidylserine and GTPase activation control Cdc42 nanoclustering to counter dissipative diffusion
por: Sartorel, Elodie, et al.
Publicado: (2018)

Cdc42 GTPase regulates ESCRTs in nuclear envelope sealing and ER remodeling
por: Lu, Michelle Seiko, et al.
Publicado: (2020)

The Small GTPase Cdc42 Is a Major Regulator of Neutrophil Effector Functions
por: Tackenberg, Heidi, et al.
Publicado: (2020)

Targeting of Cdc42 GTPase in regulatory T cells unleashes antitumor T-cell immunity
por: Kalim, Khalid W, et al.
Publicado: (2022)

Lipidation of small GTPase Cdc42 as regulator of its physiological and pathophysiological functions
por: Wirth, Alexander, et al.
Publicado: (2023)

A Rac1/Cdc42 GTPase-Specific Small Molecule Inhibitor Suppresses Growth of Primary Human Prostate Cancer Xenografts and Prolongs Survival in Mice
por: Zins, Karin, et al.
Publicado: (2013)

Roles for Rac1 and Cdc42 in planar polarization and hair outgrowth in the wing of Drosophila
Publicado: (1996)

Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis
Publicado: (1996)

Ect2 and MgcRacGAP regulate the activation and function of Cdc42 in mitosis
por: Oceguera-Yanez, Fabian, et al.
Publicado: (2005)

Plexin-B2 Negatively Regulates Macrophage Motility, Rac, and Cdc42 Activation
por: Roney, Kelly E., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_0h3gd8gm3mlsar97dgauutojlp