Point mutations in the tumor suppressor Smad4/DPC4 enhance its phosphorylation by GSK3 and reversibly inactivate TGF-β signaling

The tumor suppressor Smad4/DPC4 is an essential transcription factor in the TGF-β pathway and is frequently mutated or deleted in prostate, colorectal, and pancreatic carcinomas. We recently discovered that Smad4 activity and stability are regulated by the FGF/EGF and Wnt signaling pathways through...

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Detalles Bibliográficos
Autores principales: Demagny, Hadrien, De Robertis, Edward M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845174/
https://www.ncbi.nlm.nih.gov/pubmed/27308538
http://dx.doi.org/10.1080/23723556.2015.1025181

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845174/
https://www.ncbi.nlm.nih.gov/pubmed/27308538
http://dx.doi.org/10.1080/23723556.2015.1025181

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