Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations

RAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer (CRC) but RAF inhibitor combinations have demonstrated improved efficacy, likely through superior suppression of MAPK signaling. The first identified mechanisms of acquired resistance to these combinations all promote MAPK rea...

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Detalles Bibliográficos
Autores principales: Ahronian, Leanne G., Corcoran, Ryan B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845183/
https://www.ncbi.nlm.nih.gov/pubmed/27308562
http://dx.doi.org/10.1080/23723556.2015.1048405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845183/
https://www.ncbi.nlm.nih.gov/pubmed/27308562
http://dx.doi.org/10.1080/23723556.2015.1048405

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