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Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations
RAF inhibitor monotherapy is ineffective in BRAF-mutant colorectal cancer (CRC) but RAF inhibitor combinations have demonstrated improved efficacy, likely through superior suppression of MAPK signaling. The first identified mechanisms of acquired resistance to these combinations all promote MAPK rea...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845183/ https://www.ncbi.nlm.nih.gov/pubmed/27308562 http://dx.doi.org/10.1080/23723556.2015.1048405 |