The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into t...

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Detalles Bibliográficos
Autores principales: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://www.ncbi.nlm.nih.gov/pubmed/27308524
http://dx.doi.org/10.4161/23723548.2014.965642

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://www.ncbi.nlm.nih.gov/pubmed/27308524
http://dx.doi.org/10.4161/23723548.2014.965642

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