The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis

Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into t...

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Detalles Bibliográficos
Autores principales: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://www.ncbi.nlm.nih.gov/pubmed/27308524
http://dx.doi.org/10.4161/23723548.2014.965642
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author Shen, Jia
Sheng, Xiangpeng
Chang, ZeNan
Wu, Qian
Xie, Dong
Wang, Fudi
Hu, Ronggui
author_facet Shen, Jia
Sheng, Xiangpeng
Chang, ZeNan
Wu, Qian
Xie, Dong
Wang, Fudi
Hu, Ronggui
author_sort Shen, Jia
collection PubMed
description Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic.
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spelling pubmed-48452482016-06-15 The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis Shen, Jia Sheng, Xiangpeng Chang, ZeNan Wu, Qian Xie, Dong Wang, Fudi Hu, Ronggui Mol Cell Oncol Commentary Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into tumorigenesis associated with iron excess, but also helps guide the administration of chemotherapy based on iron deprivation in the clinic. Taylor & Francis 2014-11-03 /pmc/articles/PMC4845248/ /pubmed/27308524 http://dx.doi.org/10.4161/23723548.2014.965642 Text en © 2016 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Commentary
Shen, Jia
Sheng, Xiangpeng
Chang, ZeNan
Wu, Qian
Xie, Dong
Wang, Fudi
Hu, Ronggui
The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title_full The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title_fullStr The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title_full_unstemmed The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title_short The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
title_sort heme–p53 interaction: linking iron metabolism to p53 signaling and tumorigenesis
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/
https://www.ncbi.nlm.nih.gov/pubmed/27308524
http://dx.doi.org/10.4161/23723548.2014.965642
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