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The heme–p53 interaction: Linking iron metabolism to p53 signaling and tumorigenesis
Recently, we reported that heme binds to tumor suppressor p53 protein (TP53, best known as p53) and promotes its nuclear export and cytosolic degradation, whereas iron chelation stabilizes p53 protein and suppresses tumors in a p53-dependent manner. This not only provides mechanistic insights into t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845248/ https://www.ncbi.nlm.nih.gov/pubmed/27308524 http://dx.doi.org/10.4161/23723548.2014.965642 |