The heat shock response plays an important role in TDP-43 clearance: evidence for dysfunction in amyotrophic lateral sclerosis

Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding protein 43 (TDP-43, encoded by TARDBP ) neuronal cytoplasmic inclusions are the pathological hallmark in ∼95% of amyotrophic lateral sclerosis and ∼60% of frontotemporal lobar degeneration cases. We sought to explore the role...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Han-Jou, Mitchell, Jacqueline C., Novoselov, Sergey, Miller, Jack, Nishimura, Agnes L., Scotter, Emma L., Vance, Caroline A., Cheetham, Michael E., Shaw, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845254/
https://www.ncbi.nlm.nih.gov/pubmed/26936937
http://dx.doi.org/10.1093/brain/aww028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4845254/
https://www.ncbi.nlm.nih.gov/pubmed/26936937
http://dx.doi.org/10.1093/brain/aww028

Ejemplares similares