POH1 deubiquitylates and stabilizes E2F1 to promote tumour formation

Hyperactivation of the transcriptional factor E2F1 occurs frequently in human cancers and contributes to malignant progression. E2F1 activity is regulated by proteolysis mediated by the ubiquitin–proteasome system. However, the deubiquitylase that controls E2F1 ubiquitylation and stability remains u...

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Detalles Bibliográficos
Autores principales: Wang, Boshi, Ma, Aihui, Zhang, Li, Jin, Wei-Lin, Qian, Yu, Xu, Guiqin, Qiu, Bijun, Yang, Zhaojuan, Liu, Yun, Xia, Qiang, Liu, Yongzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846323/
https://www.ncbi.nlm.nih.gov/pubmed/26510456
http://dx.doi.org/10.1038/ncomms9704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846323/
https://www.ncbi.nlm.nih.gov/pubmed/26510456
http://dx.doi.org/10.1038/ncomms9704

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