Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force

The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands o...

Descripción completa

Detalles Bibliográficos
Autores principales: Yu, Cheng-han, Rafiq, Nisha Bte Mohd, Cao, Fakun, Zhou, Yuhuan, Krishnasamy, Anitha, Biswas, Kabir Hassan, Ravasio, Andrea, Chen, Zhongwen, Wang, Yu-Hsiu, Kawauchi, Keiko, Jones, Gareth E., Sheetz, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846324/
https://www.ncbi.nlm.nih.gov/pubmed/26507506
http://dx.doi.org/10.1038/ncomms9672

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846324/
https://www.ncbi.nlm.nih.gov/pubmed/26507506
http://dx.doi.org/10.1038/ncomms9672

Ejemplares similares