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Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force
The turnover of integrin receptors is critical for cell migration and adhesion dynamics. Here we find that force development at integrins regulates adaptor protein recruitment and endocytosis. Using mobile RGD (Arg-Gly-Asp) ligands on supported lipid membranes (RGD membranes) and rigid RGD ligands o...
Autores principales: | Yu, Cheng-han, Rafiq, Nisha Bte Mohd, Cao, Fakun, Zhou, Yuhuan, Krishnasamy, Anitha, Biswas, Kabir Hassan, Ravasio, Andrea, Chen, Zhongwen, Wang, Yu-Hsiu, Kawauchi, Keiko, Jones, Gareth E., Sheetz, Michael P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846324/ https://www.ncbi.nlm.nih.gov/pubmed/26507506 http://dx.doi.org/10.1038/ncomms9672 |
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