A single active catalytic site is sufficient to promote transport in P-glycoprotein

P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells. Better understanding of the molecular mechanism of Pgp-mediated transport could promote rational drug design to circumvent multidrug resistance. By...

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Detalles Bibliográficos
Autores principales: Bársony, Orsolya, Szalóki, Gábor, Türk, Dóra, Tarapcsák, Szabolcs, Gutay-Tóth, Zsuzsanna, Bacsó, Zsolt, Holb, Imre J., Székvölgyi, Lóránt, Szabó, Gábor, Csanády, László, Szakács, Gergely, Goda, Katalin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846820/
https://www.ncbi.nlm.nih.gov/pubmed/27117502
http://dx.doi.org/10.1038/srep24810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846820/
https://www.ncbi.nlm.nih.gov/pubmed/27117502
http://dx.doi.org/10.1038/srep24810

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