Cargando…

A single active catalytic site is sufficient to promote transport in P-glycoprotein

P-glycoprotein (Pgp) is an ABC transporter responsible for the ATP-dependent efflux of chemotherapeutic compounds from multidrug resistant cancer cells. Better understanding of the molecular mechanism of Pgp-mediated transport could promote rational drug design to circumvent multidrug resistance. By...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bársony, Orsolya, Szalóki, Gábor, Türk, Dóra, Tarapcsák, Szabolcs, Gutay-Tóth, Zsuzsanna, Bacsó, Zsolt, Holb, Imre J., Székvölgyi, Lóránt, Szabó, Gábor, Csanády, László, Szakács, Gergely, Goda, Katalin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846820/ https://www.ncbi.nlm.nih.gov/pubmed/27117502 http://dx.doi.org/10.1038/srep24810

Ejemplares similares

Interactions of retinoids with the ABC transporters P-glycoprotein and Breast Cancer Resistance Protein
por: Tarapcsák, Szabolcs, et al.
Publicado: (2017)

Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion
por: Goda, Katalin, et al.
Publicado: (2020)

Interactions of Cisplatin and Daunorubicin at the Chromatin Level
por: Firouzi Niaki, Erfaneh, et al.
Publicado: (2020)

Author Correction: Interactions of Cisplatin and Daunorubicin at the Chromatin Level
por: Firouzi Niaki, Erfaneh, et al.
Publicado: (2020)

Cholesterol-Depletion-Induced Membrane Repair Carries a Raft Conformer of P-Glycoprotein to the Cell Surface, Indicating Enhanced Cholesterol Trafficking in MDR Cells, Which Makes Them Resistant to Cholesterol Modifications
por: Gutay-Tóth, Zsuzsanna, et al.
Publicado: (2023)

NODULIN HOMEOBOX is required for heterochromatin homeostasis in Arabidopsis
por: Karányi, Zsolt, et al.
Publicado: (2022)

Aerial Laser Scanning Data as a Source of Terrain Modeling in a Fluvial Environment: Biasing Factors of Terrain Height Accuracy
por: Szabó, Zsuzsanna, et al.
Publicado: (2020)

The Role of Indoleamine-2,3-Dioxygenase in Cancer Development, Diagnostics, and Therapy
por: Hornyák, Lilla, et al.
Publicado: (2018)

Effects of Polyphenols on P-Glycoprotein (ABCB1) Activity
por: Singh, Kuljeet, et al.
Publicado: (2021)

Characterization of luteinizing hormone-releasing hormone receptor type I (LH-RH-I) as a potential molecular target in OCM-1 and OCM-3 human uveal melanoma cell lines
por: Sipos, Eva, et al.
Publicado: (2018)

The Strong In Vivo Anti-Tumor Effect of the UIC2 Monoclonal Antibody Is the Combined Result of Pgp Inhibition and Antibody Dependent Cell-Mediated Cytotoxicity
por: Szalóki, Gábor, et al.
Publicado: (2014)

Fluorescently Labeled Methyl-Beta-Cyclodextrin Enters Intestinal Epithelial Caco-2 Cells by Fluid-Phase Endocytosis
por: Fenyvesi, Ferenc, et al.
Publicado: (2014)

Nucleotide binding is the critical regulator of ABCG2 conformational transitions
por: Gyöngy, Zsuzsanna, et al.
Publicado: (2023)

(18)FDG, [(18)F]FLT, [(18)F]FAZA, and (11)C-Methionine Are Suitable Tracers for the Diagnosis and In Vivo Follow-Up of the Efficacy of Chemotherapy by miniPET in Both Multidrug Resistant and Sensitive Human Gynecologic Tumor Xenografts
por: Trencsényi, György, et al.
Publicado: (2014)

Histone H3 Lysine 56 Acetylation Is Required for Formation of Normal Levels of Meiotic DNA Breaks in S. cerevisiae
por: Karányi, Zsolt, et al.
Publicado: (2020)

Coding and noncoding transcriptomes of NODULIN HOMEOBOX (NDX)-deficient Arabidopsis inflorescence
por: Feró, Orsolya, et al.
Publicado: (2023)

Two Targets, One Hit: new Anticancer Therapeutics to Prevent Tumorigenesis Without Cardiotoxicity
por: Szabó, Zoltán, et al.
Publicado: (2021)

The targeted LHRH analog AEZS-108 alters expression of genes related to angiogenesis and development of metastasis in uveal melanoma
por: Fodor, Klara, et al.
Publicado: (2020)

NGR-peptide−drug conjugates with dual targeting properties
por: Enyedi, Kata Nóra, et al.
Publicado: (2017)

Disease-Specific Quality of Life among Patients with Peripheral Artery Disease in Hungary
por: Horváth, Lilla, et al.
Publicado: (2023)

In Silico Restriction Enzyme Digests to Minimize Mapping Bias in Genomic Sequencing
por: Roszik, Jason, et al.
Publicado: (2017)

Fully Symmetric Cyclodextrin Polycarboxylates: How to Determine Reliable Protonation Constants from NMR Titration Data
por: Kalydi, Eszter, et al.
Publicado: (2022)

Temporal Dynamics of Incidence of Shot Hole Disease Affected by Training Systems and Cultivar Susceptibilities in an Integrated Plum Orchard
por: Molnár, Bianka, et al.
Publicado: (2022)

Endogenous single-strand DNA breaks at RNA polymerase II promoters in Saccharomyces cerevisiae
por: Hegedüs, Éva, et al.
Publicado: (2018)

Disjoint Paired-Dominating sets in Cubic Graphs
por: Bacsó, Gábor, et al.
Publicado: (2019)

Down-Syndrome-Related Maternal Dysbiosis Might Be Triggered by Certain Classes of Antibiotics: A New Insight into the Possible Pathomechanisms
por: Ternák, Gábor, et al.
Publicado: (2023)

Environment-dependence of behavioural consistency in adult male European green lizards (Lacerta viridis)
por: Horváth, Gergely, et al.
Publicado: (2017)

Concurrence of chromosome 3 and 4 aberrations in human uveal melanoma
por: Sipos, Eva, et al.
Publicado: (2017)

Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats
por: Ibos, Katalin Eszter, et al.
Publicado: (2021)

Correlation between the Expression of Angiogenic Factors and Stem Cell Markers in Human Uveal Melanoma
por: Fodor, Klára, et al.
Publicado: (2020)

Targeting Nuclear NAD(+) Synthesis Inhibits DNA Repair, Impairs Metabolic Adaptation and Increases Chemosensitivity of U-2OS Osteosarcoma Cells
por: Kiss, Alexandra, et al.
Publicado: (2020)

FSRD: fungal stress response database
por: Karányi, Zsolt, et al.
Publicado: (2013)

Genome-wide mapping of binding sites of the transposase-derived SETMAR protein in the human genome
por: Miskei, Márton, et al.
Publicado: (2021)

Nuclear dynamics of the Set1C subunit Spp1 prepares meiotic recombination sites for break formation
por: Karányi, Zsolt, et al.
Publicado: (2018)

Improved Micro-X-ray Fluorescence Confocal Imaging of Two-Dimensional Distribution of Arsenic Concentration in Cucumber Hypocotyls Using Synchrotron Radiation
por: Szalóki, Imre, et al.
Publicado: (2021)

Characterization of Disease-Associated Mutations in Human Transmembrane Proteins
por: Molnár, János, et al.
Publicado: (2016)

RNA-DNA hybrid (R-loop) immunoprecipitation mapping: an analytical workflow to evaluate inherent biases
por: Halász, László, et al.
Publicado: (2017)

Evaluation of Retinal Blood Flow in Patients with Monoclonal Gammopathy Using OCT Angiography
por: Czakó, Cecilia, et al.
Publicado: (2023)

Attractiveness of thermally different, uniformly black targets to horseflies: Tabanus tergestinus prefers sunlit warm shiny dark targets
por: Horváth, Gábor, et al.
Publicado: (2019)

Efficacy of Treatments in Nonarteritic Ischemic Optic Neuropathy: A Systematic Review and Meta-Analysis
por: Lantos, Krisztina, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_ba36o7he7qg81f5d28t2l69b32