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Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity
G protein-coupled receptors (GPCRs) are an important class of drug targets. Quantitative analysis by global curve fitting of properly designed dose-dependent GPCR agonism and allosterism data permits the determination of all affinity and efficacy parameters based on a general operational model. We r...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846876/ https://www.ncbi.nlm.nih.gov/pubmed/27116909 http://dx.doi.org/10.1038/srep25158 |