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Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity

G protein-coupled receptors (GPCRs) are an important class of drug targets. Quantitative analysis by global curve fitting of properly designed dose-dependent GPCR agonism and allosterism data permits the determination of all affinity and efficacy parameters based on a general operational model. We r...

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Detalles Bibliográficos
Autores principales: Zhang, Rumin, Kavana, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846876/
https://www.ncbi.nlm.nih.gov/pubmed/27116909
http://dx.doi.org/10.1038/srep25158