Cargando…
Quantitative Measure of Receptor Agonist and Modulator Equi-Response and Equi-Occupancy Selectivity
G protein-coupled receptors (GPCRs) are an important class of drug targets. Quantitative analysis by global curve fitting of properly designed dose-dependent GPCR agonism and allosterism data permits the determination of all affinity and efficacy parameters based on a general operational model. We r...
| Autores principales: | , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4846876/ https://www.ncbi.nlm.nih.gov/pubmed/27116909 http://dx.doi.org/10.1038/srep25158 |