LIMK Regulates Tumor-Cell Invasion and Matrix Degradation Through Tyrosine Phosphorylation of MT1-MMP

During their metastatic spread, cancer cells need to remodel the extracellular matrix in order to migrate through stromal compartments adjacent to the primary tumor. Dissemination of breast carcinoma cells is mediated by membrane type 1-matrix metalloproteinase (MT1-MMP/MMP14), the main invadopodial...

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Detalles Bibliográficos
Autores principales: Lagoutte, Emilie, Villeneuve, Clémentine, Lafanechère, Laurence, Wells, Claire M., Jones, Gareth E., Chavrier, Philippe, Rossé, Carine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847008/
https://www.ncbi.nlm.nih.gov/pubmed/27116935
http://dx.doi.org/10.1038/srep24925

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847008/
https://www.ncbi.nlm.nih.gov/pubmed/27116935
http://dx.doi.org/10.1038/srep24925

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