C1, a highly potent novel curcumin derivative, binds to tubulin, disrupts microtubule network and induces apoptosis

We have synthesized a curcumin derivative, 4-{5-(4-hydroxy-3-methoxy-phenyl)-2-[3-(4-hydroxy-3-methoxy-phenyl)-acryloyl]-3-oxo-penta-1,4-dienyl}-piperidine-1-carboxylic acid tert-butyl ester (C1) that displays much stronger antiproliferative activity against various types of cancer cells including m...

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Detalles Bibliográficos
Autores principales: Srivastava, Shalini, Mishra, Satyendra, Surolia, Avadhesha, Panda, Dulal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2016
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847174/
https://www.ncbi.nlm.nih.gov/pubmed/26980197
http://dx.doi.org/10.1042/BSR20160039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847174/
https://www.ncbi.nlm.nih.gov/pubmed/26980197
http://dx.doi.org/10.1042/BSR20160039

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