Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model

BACKGROUND: A certain number of mutations in the Microtubule-Associated Protein Tau (MAPT) gene have been identified in individuals with high risk to develop neurodegenerative diseases, collectively called tauopathies. The mutation A152TMAPT was recently identified in patients diagnosed with frontot...

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Detalles Bibliográficos
Autores principales: Pir, Ghulam Jeelani, Choudhary, Bikash, Mandelkow, Eckhard, Mandelkow, Eva-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847334/
https://www.ncbi.nlm.nih.gov/pubmed/27118310
http://dx.doi.org/10.1186/s13024-016-0096-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847334/
https://www.ncbi.nlm.nih.gov/pubmed/27118310
http://dx.doi.org/10.1186/s13024-016-0096-1

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