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Chemical generation and modification of peptides containing multiple dehydroalanines

Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used t...

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Detalles Bibliográficos
Autores principales: Morrison, Philip M., Foley, Patrick J., Warriner, Stuart L., Webb, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847484/
https://www.ncbi.nlm.nih.gov/pubmed/26219458
http://dx.doi.org/10.1039/c5cc05469a