Chemical generation and modification of peptides containing multiple dehydroalanines

Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used t...

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Detalles Bibliográficos
Autores principales: Morrison, Philip M., Foley, Patrick J., Warriner, Stuart L., Webb, Michael E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2015
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847484/
https://www.ncbi.nlm.nih.gov/pubmed/26219458
http://dx.doi.org/10.1039/c5cc05469a
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author Morrison, Philip M.
Foley, Patrick J.
Warriner, Stuart L.
Webb, Michael E.
author_facet Morrison, Philip M.
Foley, Patrick J.
Warriner, Stuart L.
Webb, Michael E.
author_sort Morrison, Philip M.
collection PubMed
description Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation.
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spelling pubmed-48474842016-05-03 Chemical generation and modification of peptides containing multiple dehydroalanines Morrison, Philip M. Foley, Patrick J. Warriner, Stuart L. Webb, Michael E. Chem Commun (Camb) Chemistry Chemical formation of dehydroalanine has been widely used for the post-translational modification of proteins and peptides, however methods to incorporate multiple dehydroalanine residues into a single peptide have not been defined. We report the use of methyl 2,5-dibromovalerate which can be used to cleanly carry out this transformation. Royal Society of Chemistry 2015-09-11 2015-07-29 /pmc/articles/PMC4847484/ /pubmed/26219458 http://dx.doi.org/10.1039/c5cc05469a Text en This journal is © The Royal Society of Chemistry 2015 http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported License (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Chemistry
Morrison, Philip M.
Foley, Patrick J.
Warriner, Stuart L.
Webb, Michael E.
Chemical generation and modification of peptides containing multiple dehydroalanines
title Chemical generation and modification of peptides containing multiple dehydroalanines
title_full Chemical generation and modification of peptides containing multiple dehydroalanines
title_fullStr Chemical generation and modification of peptides containing multiple dehydroalanines
title_full_unstemmed Chemical generation and modification of peptides containing multiple dehydroalanines
title_short Chemical generation and modification of peptides containing multiple dehydroalanines
title_sort chemical generation and modification of peptides containing multiple dehydroalanines
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847484/
https://www.ncbi.nlm.nih.gov/pubmed/26219458
http://dx.doi.org/10.1039/c5cc05469a
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