RUNX1 and its fusion oncoprotein derivative RUNX1-ETO induce senescence-like growth arrest independently of replicative stress

A role for the RUNX genes in cancer failsafe processes has been suggested by their induction of senescence-like growth arrest in primary murine fibroblasts and the failure of RAS-induced senescence in Runx2 deficient cells. We now show that RUNX1 induces senescence in human primary fibroblasts. High...

Descripción completa

Detalles Bibliográficos
Autores principales: Wolyniec, Kamil, Wotton, Sandy, Kilbey, Anna, Jenkins, Alma, Terry, Anne, Peters, Gordon, Stocking, Carol, Cameron, Ewan, Neil, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847638/
https://www.ncbi.nlm.nih.gov/pubmed/19448675
http://dx.doi.org/10.1038/onc.2009.101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4847638/
https://www.ncbi.nlm.nih.gov/pubmed/19448675
http://dx.doi.org/10.1038/onc.2009.101

Ejemplares similares