Nanopore sequencing detects structural variants in cancer

Despite advances in sequencing, structural variants (SVs) remain difficult to reliably detect due to the short read length (<300 bp) of 2nd generation sequencing. Not only do the reads (or paired-end reads) need to straddle a breakpoint, but repetitive elements often lead to ambiguities in the al...

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Detalles Bibliográficos
Autores principales: Norris, Alexis L., Workman, Rachael E., Fan, Yunfan, Eshleman, James R., Timp, Winston
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848001/
https://www.ncbi.nlm.nih.gov/pubmed/26787508
http://dx.doi.org/10.1080/15384047.2016.1139236

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848001/
https://www.ncbi.nlm.nih.gov/pubmed/26787508
http://dx.doi.org/10.1080/15384047.2016.1139236

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