Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, we used whole-genome sequences from 498 strains of M. tuberculosis to identif...

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Detalles Bibliográficos
Autores principales: Desjardins, Christopher A., Cohen, Keira A., Munsamy, Vanisha, Abeel, Thomas, Maharaj, Kashmeel, Walker, Bruce J., Shea, Terrance P., Almeida, Deepak V., Manson, Abigail L., Salazar, Alex, Padayatchi, Nesri, O’Donnell, Max R., Mlisana, Koleka P., Wortman, Jennifer, Birren, Bruce W., Grosset, Jacques, Earl, Ashlee M., Pym, Alexander S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848111/
https://www.ncbi.nlm.nih.gov/pubmed/27064254
http://dx.doi.org/10.1038/ng.3548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848111/
https://www.ncbi.nlm.nih.gov/pubmed/27064254
http://dx.doi.org/10.1038/ng.3548

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