Cargando…

Genomic and functional analyses of Mycobacterium tuberculosis strains implicate ald in D-cycloserine resistance

A more complete understanding of the genetic basis of drug resistance in Mycobacterium tuberculosis is critical for prompt diagnosis and optimal treatment, particularly for toxic second-line drugs like D-cycloserine. Here, we used whole-genome sequences from 498 strains of M. tuberculosis to identif...

Descripción completa

Detalles Bibliográficos
Autores principales:	Desjardins, Christopher A., Cohen, Keira A., Munsamy, Vanisha, Abeel, Thomas, Maharaj, Kashmeel, Walker, Bruce J., Shea, Terrance P., Almeida, Deepak V., Manson, Abigail L., Salazar, Alex, Padayatchi, Nesri, O’Donnell, Max R., Mlisana, Koleka P., Wortman, Jennifer, Birren, Bruce W., Grosset, Jacques, Earl, Ashlee M., Pym, Alexander S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848111/ https://www.ncbi.nlm.nih.gov/pubmed/27064254 http://dx.doi.org/10.1038/ng.3548

Ejemplares similares

Evolution of Extensively Drug-Resistant Tuberculosis over Four Decades: Whole Genome Sequencing and Dating Analysis of Mycobacterium tuberculosis Isolates from KwaZulu-Natal
por: Cohen, Keira A., et al.
Publicado: (2015)

Whole-Transcriptome and -Genome Analysis of Extensively Drug-Resistant Mycobacterium tuberculosis Clinical Isolates Identifies Downregulation of ethA as a Mechanism of Ethionamide Resistance
por: de Welzen, Lynne, et al.
Publicado: (2017)

Extensive global movement of multidrug-resistant M. tuberculosis strains revealed by whole-genome analysis
por: Cohen, Keira A, et al.
Publicado: (2019)

Deciphering drug resistance in Mycobacterium tuberculosis using whole-genome sequencing: progress, promise, and challenges
por: Cohen, Keira A., et al.
Publicado: (2019)

Fatal Nosocomial MDR TB Identified through Routine Genetic Analysis and Whole-Genome Sequencing
por: Williams, O. Martin, et al.
Publicado: (2015)

Normalizing alternate representations of large sequence variants across multiple bacterial genomes
por: Salazar, Alex, et al.
Publicado: (2015)

Draft Genome Sequences of Two Extensively Drug-Resistant Strains of Mycobacterium tuberculosis Belonging to the Euro-American S Lineage
por: Malinga, Lesibana A., et al.
Publicado: (2016)

Pilon: An Integrated Tool for Comprehensive Microbial Variant Detection and Genome Assembly Improvement
por: Walker, Bruce J., et al.
Publicado: (2014)

High incidence and persistence of hepatitis B virus infection in individuals receiving HIV care in KwaZulu-Natal, South Africa
por: Msomi, Nokukhanya, et al.
Publicado: (2020)

QuantTB – a method to classify mixed Mycobacterium tuberculosis infections within whole genome sequencing data
por: Anyansi, Christine, et al.
Publicado: (2020)

Whole Genome Sequencing of Mycobacterium africanum Strains from Mali Provides Insights into the Mechanisms of Geographic Restriction
por: Winglee, Kathryn, et al.
Publicado: (2016)

Cycloserine induced mania
por: Bakhla, Ajay Kumar, et al.
Publicado: (2013)

Computational Methods for Strain-Level Microbial Detection in Colony and Metagenome Sequencing Data
por: Anyansi, Christine, et al.
Publicado: (2020)

Dynamics of within-host Mycobacterium tuberculosis diversity and heteroresistance during treatment
por: Nimmo, Camus, et al.
Publicado: (2020)

Evolution of Invasion in a Diverse Set of Fusobacterium Species
por: Manson McGuire, Abigail, et al.
Publicado: (2014)

Paradoxical Hypersusceptibility of Drug-resistant Mycobacteriumtuberculosis to β-lactam Antibiotics
por: Cohen, Keira A., et al.
Publicado: (2016)

SynerClust: a highly scalable, synteny-aware orthologue clustering tool
por: Georgescu, Christophe H., et al.
Publicado: (2018)

Cycloserine induced psychosis with hepatic dysfunction
por: Tandon, Vishal R., et al.
Publicado: (2015)

Population-level emergence of bedaquiline and clofazimine resistance-associated variants among patients with drug-resistant tuberculosis in southern Africa: a phenotypic and phylogenetic analysis
por: Nimmo, Camus, et al.
Publicado: (2020)

Whole-Genome Sequencing of Mycobacterium tuberculosis Provides Insight into the Evolution and Genetic Composition of Drug-Resistant Tuberculosis in Belarus
por: Wollenberg, Kurt R., et al.
Publicado: (2017)

Emergence of Epidemic Multidrug-Resistant Enterococcus faecium from Animal and Commensal Strains
por: Lebreton, François, et al.
Publicado: (2013)

Bedaquiline resistance in drug-resistant tuberculosis HIV co-infected patients
por: Nimmo, Camus, et al.
Publicado: (2020)

Neuroleptic malignant syndrome in cycloserine-induced psychosis
por: Sawant, Neena S., et al.
Publicado: (2015)

Cycloserine Population Pharmacokinetics and Pharmacodynamics in Patients with Tuberculosis
por: Alghamdi, Wael A., et al.
Publicado: (2019)

Deterioration of Cycloserine in Drug Susceptibility Testing of Mycobacterium
por: Wang, Ruibai, et al.
Publicado: (2022)

Dual-Reporter Mycobacteriophages (Φ(2)DRMs) Reveal Preexisting Mycobacterium tuberculosis Persistent Cells in Human Sputum
por: Jain, Paras, et al.
Publicado: (2016)

The whole is greater than the sum of the parts: Recognising missed opportunities for an optimal response to the rapidly maturing TB-HIV co-epidemic in South Africa
por: Perumal, Rubeshan, et al.
Publicado: (2009)

The contrasting cultures of HIV and tuberculosis care
por: Daftary, Amrita, et al.
Publicado: (2015)

TB epidemiology: where are the young women? Know your tuberculosis epidemic, know your response
por: Perumal, Rubeshan, et al.
Publicado: (2018)

A comprehensive characterization of PncA polymorphisms that confer resistance to pyrazinamide
por: Yadon, Adam N., et al.
Publicado: (2017)

XDR-TB in South Africa: No Time for Denial or Complacency
por: Singh, Jerome Amir, et al.
Publicado: (2007)

D-Cycloserine in Neuropsychiatric Diseases: A Systematic Review
por: Schade, Sebastian, et al.
Publicado: (2015)

Treatment Outcomes for Extensively Drug-Resistant Tuberculosis and HIV Co-infection
por: O’Donnell, Max R., et al.
Publicado: (2013)

Understanding the Profile of Tuberculosis and Human Immunodeficiency Virus Coinfection: Insights from Expanded HIV Surveillance at a Tuberculosis Facility in Durban, South Africa
por: Perumal, Rubeshan, et al.
Publicado: (2014)

Application of Next Generation Sequencing for Diagnosis and Clinical Management of Drug-Resistant Tuberculosis: Updates on Recent Developments in the Field
por: Dookie, Navisha, et al.
Publicado: (2022)

A Rapid Drug Resistance Genotyping Workflow for Mycobacterium tuberculosis, Using Targeted Isothermal Amplification and Nanopore Sequencing
por: Gliddon, Harriet D., et al.
Publicado: (2021)

d-Cycloserine destruction by alanine racemase and the limit of irreversible inhibition
por: de Chiara, Cesira, et al.
Publicado: (2020)

The successful use of amphotericin B followed by oral posaconazole in a rare case of invasive fungal sinusitis caused by co-infection with mucormycosis and aspergillus
por: Mahomed, Sharana, et al.
Publicado: (2015)

Resazurin microtitre plate assay and Sensititre® MycoTB for detection of Mycobacterium tuberculosis resistance in a high tuberculosis resistance setting
por: Jaglal, Prenika, et al.
Publicado: (2019)

High quality draft genome sequence of Segniliparus rugosus CDC 945(T)= (ATCC BAA-974(T))
por: Earl, Ashlee M., et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_9124n3ksn86g0fn3bng4an7lv3