Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer

Cancer cells often select for mutations that enhance signaling through pathways that promote anabolic metabolism(1). Although the PI3K/Akt signaling pathway, which is frequently dysregulated in breast cancer(2), is a well-established regulator of central glucose metabolism and aerobic glycolysis(3,4...

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Detalles Bibliográficos
Autores principales: Lien, Evan C., Lyssiotis, Costas A., Juvekar, Ashish, Hu, Hai, Asara, John M., Cantley, Lewis C., Toker, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114/
https://www.ncbi.nlm.nih.gov/pubmed/27088857
http://dx.doi.org/10.1038/ncb3341

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114/
https://www.ncbi.nlm.nih.gov/pubmed/27088857
http://dx.doi.org/10.1038/ncb3341

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