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Glutathione biosynthesis is a metabolic vulnerability in PI3K/Akt-driven breast cancer
Cancer cells often select for mutations that enhance signaling through pathways that promote anabolic metabolism(1). Although the PI3K/Akt signaling pathway, which is frequently dysregulated in breast cancer(2), is a well-established regulator of central glucose metabolism and aerobic glycolysis(3,4...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848114/ https://www.ncbi.nlm.nih.gov/pubmed/27088857 http://dx.doi.org/10.1038/ncb3341 |