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Proline-based Phosphoramidite Reagents for the Reductive Ligation of S-Nitrosothiols

S-Nitrosothiols have many biological implications but are rarely used in organic synthesis. In this work we report the development of proline-based phosphoramidite substrates that can effectively convert S-nitrosothiols to proline-based sulfenamides through a reductive ligation process. A unique pro...

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Detalles Bibliográficos
Autores principales: Park, Chung-Min, Biggs, Tyler D., Xian, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848125/
https://www.ncbi.nlm.nih.gov/pubmed/26758493
http://dx.doi.org/10.1038/ja.2015.144