Foldamer-mediated manipulation of a pre-amyloid toxin

Disordered proteins, such as those central to Alzheimer's and Parkinson's, are particularly intractable for structure-targeted therapeutic design. Here we demonstrate the capacity of a synthetic foldamer to capture structure in a disease relevant peptide. Oligoquinoline amides have a defin...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Sunil, Birol, Melissa, Schlamadinger, Diana E., Wojcik, Slawomir P., Rhoades, Elizabeth, Miranker, Andrew D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848510/
https://www.ncbi.nlm.nih.gov/pubmed/27108700
http://dx.doi.org/10.1038/ncomms11412

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848510/
https://www.ncbi.nlm.nih.gov/pubmed/27108700
http://dx.doi.org/10.1038/ncomms11412

Ejemplares similares