Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions

Mitochondrial DNA (mtDNA) mutations are a common cause of primary mitochondrial disorders, and have also been implicated in a broad collection of conditions, including aging, neurodegeneration, and cancer. Prevalent among these pathogenic variants are mtDNA deletions, which show a strong bias for th...

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Detalles Bibliográficos
Autores principales: Belmonte, Frances R., Martin, James L., Frescura, Kristin, Damas, Joana, Pereira, Filipe, Tarnopolsky, Mark A., Kaufman, Brett A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848546/
https://www.ncbi.nlm.nih.gov/pubmed/27122135
http://dx.doi.org/10.1038/srep25186

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848546/
https://www.ncbi.nlm.nih.gov/pubmed/27122135
http://dx.doi.org/10.1038/srep25186

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