Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

Different HCV subtypes may naturally harbor different resistance selection to anti-NS5a inhibitors. 2761 sequences retrieved from the Los Alamos HCV database were analyzed in the NS5a domain 1, the target of NS5a inhibitors. The NS5a resistance-associated polymorphisms (RAPs) were more frequently de...

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Detalles Bibliográficos
Autores principales: Bagaglio, Sabrina, Andolina, Andrea, Merli, Marco, Uberti-Foppa, Caterina, Morsica, Giulia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848586/
https://www.ncbi.nlm.nih.gov/pubmed/27023593
http://dx.doi.org/10.3390/v8040091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848586/
https://www.ncbi.nlm.nih.gov/pubmed/27023593
http://dx.doi.org/10.3390/v8040091

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