Cargando…

Frequency of Natural Resistance within NS5a Replication Complex Domain in Hepatitis C Genotypes 1a, 1b: Possible Implication of Subtype-Specific Resistance Selection in Multiple Direct Acting Antivirals Drugs Combination Treatment

Different HCV subtypes may naturally harbor different resistance selection to anti-NS5a inhibitors. 2761 sequences retrieved from the Los Alamos HCV database were analyzed in the NS5a domain 1, the target of NS5a inhibitors. The NS5a resistance-associated polymorphisms (RAPs) were more frequently de...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bagaglio, Sabrina, Andolina, Andrea, Merli, Marco, Uberti-Foppa, Caterina, Morsica, Giulia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848586/ https://www.ncbi.nlm.nih.gov/pubmed/27023593 http://dx.doi.org/10.3390/v8040091

Ejemplares similares

A Prospective Italian Study on Baseline NS3 and NS5A Resistance to Direct-Acting Antivirals in a Real-World Setting of HIV-1/HCV Coinfected Patients and Association with Treatment Outcome
por: Bagaglio, Sabrina, et al.
Publicado: (2020)

Compartmentalization of Resistance-Associated Substitutions in HIV/HCV-Infected Patients: Possible Correlation with Infecting HCV Genotype
por: Morsica, Giulia, et al.
Publicado: (2021)

Natural polymorphisms in the resistance associated sites of HCV-G1 NS5B domain and correlation with geographic origin of HCV isolates
por: Bagaglio, Sabrina, et al.
Publicado: (2018)

Geographic Distribution of HCV-GT3 Subtypes and Naturally Occurring Resistance Associated Substitutions
por: Bagaglio, Sabrina, et al.
Publicado: (2019)

Risk of HIV viral rebound in HIV infected patients on direct acting antivirals (DAAs) treatment for HCV
por: Morsica, Giulia, et al.
Publicado: (2022)

Dynamic of Mixed HCV Infection in Plasma and PBMC of HIV/HCV Patients Under Treatment With Peg-IFN/Ribavirin
por: Bagaglio, Sabrina, et al.
Publicado: (2015)

Virological pattern of hepatitis B infection in an HIV-positive man with fatal fulminant hepatitis B: a case report
por: Bagaglio, Sabrina, et al.
Publicado: (2009)

Immune response to hepatitis B vaccination in HIV-positive individuals with isolated antibodies against hepatitis B core antigen: Results of a prospective Italian study
por: Morsica, Giulia, et al.
Publicado: (2017)

Levels of Alpha-Fetoprotein and Association with Mortality in Hepatocellular Carcinoma of HIV-1-Infected Patients
por: Morsica, Giulia, et al.
Publicado: (2022)

Modelling the impact of protein-kinase R allelic variant on HIV biomarkers trajectories by means of latent class mixed models
por: Brombin, Chiara, et al.
Publicado: (2022)

Molecular epidemiology of HIV-1 infection in immigrant population in northern Italy
por: Sagnelli, Caterina, et al.
Publicado: (2020)

Characterization of primary direct-acting antiviral (DAA) drugs resistance mutations in NS5A/NS5B regions of hepatitis C virus with genotype 1a and 1b from patients with chronic hepatitis
por: Santos, Ana Paula de Torres, et al.
Publicado: (2022)

Survival in People Living with HIV with or without Recurrence of Hepatocellular Carcinoma after Invasive Therapy
por: Bertoni, Costanza, et al.
Publicado: (2023)

An NS5A single optimized method to determine genotype, subtype and resistance profiles of Hepatitis C strains
por: Andre-Garnier, Elisabeth, et al.
Publicado: (2017)

Prevalence of Single and Multiple Natural NS3, NS5A and NS5B Resistance-Associated Substitutions in Hepatitis C Virus Genotypes 1–4 in Italy
por: Bertoli, Ada, et al.
Publicado: (2018)

Characterization of Naturally Occurring NS5A and NS5B Polymorphisms in Patients Infected with HCV Genotype 3a Treated with Direct-Acting Antiviral Agents
por: Bartolini, Barbara, et al.
Publicado: (2017)

Performance of NS3, NS5a AND NS5b Hepatitis C Virus (HCV) Antiviral Resistance Sequencing Assays
por: Nutt, Jamie, et al.
Publicado: (2017)

The incidence of resistance-associated variants to NS5A in HCV subtypes 1a and 1b in Taiwan
por: Tsai, Ming-Chao, et al.
Publicado: (2021)

Structural and Functional Analysis of NS1 and NS2 Proteins of H1N1 Subtype
por: Salahuddin, Parveen, et al.
Publicado: (2010)

Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients
por: Aldunate, Fabián, et al.
Publicado: (2018)

Detection of low-level HCV variants in DAA treated patients: comparison amongst three different NGS data analysis protocols
por: Caputo, Valeria, et al.
Publicado: (2020)

NS3 Resistance-Associated Variants (RAVs) in Patients Infected with HCV Genotype 1a in Spain
por: Jimenez-Sousa, María Ángeles, et al.
Publicado: (2016)

Genetic Diversity and Selective Pressure in Hepatitis C Virus Genotypes 1–6: Significance for Direct-Acting Antiviral Treatment and Drug Resistance
por: Cuypers, Lize, et al.
Publicado: (2015)

Prevalence and Factors Related to Natural Resistance-Associated Substitutions to Direct-Acting Antivirals in Patients with Genotype 1 Hepatitis C Virus Infection
por: Esposito, Isabella, et al.
Publicado: (2018)

Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”
por: Eybpoosh, Sana, et al.
Publicado: (2018)

Consideration of Viral Resistance for Optimization of Direct Antiviral Therapy of Hepatitis C Virus Genotype 1-Infected Patients
por: Dietz, Julia, et al.
Publicado: (2015)

Response to: Comment on “Pretreatment Hepatitis C Virus NS5A/NS5B Resistance-Associated Substitutions in Genotype 1 Uruguayan Infected Patients”
por: Aldunate, Fabián, et al.
Publicado: (2019)

Selection dynamics of HCV genotype 3 resistance-associated substitutions under direct-acting antiviral therapy pressure
por: Rodrigues, João Paulo Vilela, et al.
Publicado: (2022)

High frequency of antiviral drug resistance and non-b subtypes in HIV-1 patients failing antiviral therapy in Cuba
por: Kouri, Vivian, et al.
Publicado: (2014)

Direct-acting Antiviral Agents Resistance-associated Polymorphisms in Chinese Treatment-naïve Patients Infected with Genotype 1b Hepatitis C Virus
por: Wang, Ye, et al.
Publicado: (2015)

Direct Binding of Ledipasvir to HCV NS5A: Mechanism of Resistance to an HCV Antiviral Agent
por: Kwon, Hyock Joo, et al.
Publicado: (2015)

Role of HIV Subtype Diversity in the Development of Resistance to Antiviral Drugs
por: Wainberg, Mark A., et al.
Publicado: (2010)

Characterization of NS5A and NS5B Resistance-Associated Substitutions from Genotype 1 Hepatitis C Virus Infected Patients in a Portuguese Cohort
por: Brandão, Ruben, et al.
Publicado: (2018)

TRIM22 suppresses Zika virus replication by targeting NS1 and NS3 for proteasomal degradation
por: Zu, Shulong, et al.
Publicado: (2022)

Pegylated-interferon plus ribavirin treatment does not alter the prevalence of resistance-associated substitutions to direct-acting antivirals in HCV genotype 1a patients
por: Chen, Zhi-wei, et al.
Publicado: (2017)

Non-epidemic HCV genotypes in low- and middle-income countries and the risk of resistance to current direct-acting antiviral regimens
por: Shah, Rajiv, et al.
Publicado: (2021)

Mechanisms of Hepatitis C Viral Resistance to Direct Acting Antivirals
por: Ahmed, Asma, et al.
Publicado: (2015)

Computational analysis of naturally occurring resistance-associated substitutions in genes NS3, NS5A, and NS5B among 86 subtypes of hepatitis C virus worldwide
por: Wu, Ruihong, et al.
Publicado: (2019)

In Silico Prediction of the Phosphorylation of NS3 as an Essential Mechanism for Dengue Virus Replication and the Antiviral Activity of Quercetin
por: Alomair, Lamya, et al.
Publicado: (2021)

Can Natural Polyphenols Help in Reducing Cytokine Storm in COVID-19 Patients?
por: Giovinazzo, Giovanna, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_i4dnqtveei9495ejlr74s3luk1