ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus α-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes

The Staphylococcus aureus toxin, α-hemolysin, is an important and well-studied virulence factor in staphylococcal infection. It is a soluble monomeric protein that, once secreted by the bacterium, forms a heptameric pore in the membrane of a broad range of host cell types. Hemolysin was recently dis...

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Detalles Bibliográficos
Autores principales: Ezekwe, Ejiofor A.D., Weng, Chengyu, Duncan, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848622/
https://www.ncbi.nlm.nih.gov/pubmed/27043625
http://dx.doi.org/10.3390/toxins8040095

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848622/
https://www.ncbi.nlm.nih.gov/pubmed/27043625
http://dx.doi.org/10.3390/toxins8040095

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