Insulin Protects Hepatic Lipotoxicity by Regulating ER Stress through the PI3K/Akt/p53 Involved Pathway Independently of Autophagy Inhibition

The detrimental role of hepatic lipotoxicity has been well-implicated in the pathogenesis of NAFLD. Previously, we reported that inhibiting autophagy aggravated saturated fatty acid (SFA)-induced hepatotoxicity. Insulin, a physiological inhibitor of autophagy, is commonly increased within NAFLD main...

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Detalles Bibliográficos
Autores principales: Ning, Hua, Sun, Zongxiang, Liu, Yunyun, Liu, Lei, Hao, Liuyi, Ye, Yaxin, Feng, Rennan, Li, Jie, Li, Ying, Chu, Xia, Li, Songtao, Sun, Changhao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848695/
https://www.ncbi.nlm.nih.gov/pubmed/27104558
http://dx.doi.org/10.3390/nu8040227

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848695/
https://www.ncbi.nlm.nih.gov/pubmed/27104558
http://dx.doi.org/10.3390/nu8040227

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