Ex vivo imaging of active caspase 3 by a FRET-based molecular probe demonstrates the cellular dynamics and localization of the protease in cerebellar granule cells and its regulation by the apoptosis-inhibiting protein survivin

BACKGROUND: Apoptosis takes place in naturally occurring neuronal death, but also in aging, neurodegenerative disorders, and traumatic brain injuries. Caspase 3 (Casp3) is the most important effector protease in apoptosis: being inactive inside the cell, it undergoes enzymatic cleavage and - hence -...

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Detalles Bibliográficos
Autores principales: Lossi, Laura, Cocito, Carolina, Alasia, Silvia, Merighi, Adalberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848850/
https://www.ncbi.nlm.nih.gov/pubmed/27122136
http://dx.doi.org/10.1186/s13024-016-0101-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848850/
https://www.ncbi.nlm.nih.gov/pubmed/27122136
http://dx.doi.org/10.1186/s13024-016-0101-8

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