SAAFEC: Predicting the Effect of Single Point Mutations on Protein Folding Free Energy Using a Knowledge-Modified MM/PBSA Approach

Folding free energy is an important biophysical characteristic of proteins that reflects the overall stability of the 3D structure of macromolecules. Changes in the amino acid sequence, naturally occurring or made in vitro, may affect the stability of the corresponding protein and thus could be asso...

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Detalles Bibliográficos
Autores principales: Getov, Ivan, Petukh, Marharyta, Alexov, Emil
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848968/
https://www.ncbi.nlm.nih.gov/pubmed/27070572
http://dx.doi.org/10.3390/ijms17040512

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848968/
https://www.ncbi.nlm.nih.gov/pubmed/27070572
http://dx.doi.org/10.3390/ijms17040512

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