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Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic
We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849009/ https://www.ncbi.nlm.nih.gov/pubmed/27089321 http://dx.doi.org/10.3390/ijms17040553 |
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author | Flores-Figueroa, Eugenia Gratzinger, Dita |
author_facet | Flores-Figueroa, Eugenia Gratzinger, Dita |
author_sort | Flores-Figueroa, Eugenia |
collection | PubMed |
description | We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we provide a model that incorporates in vitro and in vivo models as well as in situ findings from intact human marrow to explain the changes seen in myelodysplastic syndrome patients. We highlight the clinical application of the study of the bone marrow microenvironment and its topobiology in myelodysplastic syndromes. |
format | Online Article Text |
id | pubmed-4849009 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-48490092016-05-04 Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic Flores-Figueroa, Eugenia Gratzinger, Dita Int J Mol Sci Review We review the murine and human microenvironment and hematopoietic stem cell niche in the context of intact bone marrow architecture in man and mouse, both in normal and in myelodysplastic syndrome marrow. We propose that the complexity of the hematopoietic stem cell niche can usefully be approached in the context of its topobiology, and we provide a model that incorporates in vitro and in vivo models as well as in situ findings from intact human marrow to explain the changes seen in myelodysplastic syndrome patients. We highlight the clinical application of the study of the bone marrow microenvironment and its topobiology in myelodysplastic syndromes. MDPI 2016-04-13 /pmc/articles/PMC4849009/ /pubmed/27089321 http://dx.doi.org/10.3390/ijms17040553 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Flores-Figueroa, Eugenia Gratzinger, Dita Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title | Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title_full | Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title_fullStr | Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title_full_unstemmed | Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title_short | Beyond the Niche: Myelodysplastic Syndrome Topobiology in the Laboratory and in the Clinic |
title_sort | beyond the niche: myelodysplastic syndrome topobiology in the laboratory and in the clinic |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849009/ https://www.ncbi.nlm.nih.gov/pubmed/27089321 http://dx.doi.org/10.3390/ijms17040553 |
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