FGF1 C-terminal domain and phosphorylation regulate intracrine FGF1 signaling for its neurotrophic and anti-apoptotic activities

Fibroblast growth factor 1 (FGF1) is a prototypic member of the FGFs family overexpressed in various tumors. Contrarily to most FGFs, FGF1 lacks a secretion peptide signal and acts mainly in an intracellular and nuclear manner. Intracellular FGF1 induces cell proliferation, differentiation and survi...

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Detalles Bibliográficos
Autores principales: Delmas, E, Jah, N, Pirou, C, Bouleau, S, Le Floch, N, Vayssière, J-L, Mignotte, B, Renaud, F
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849156/
https://www.ncbi.nlm.nih.gov/pubmed/26844696
http://dx.doi.org/10.1038/cddis.2016.2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849156/
https://www.ncbi.nlm.nih.gov/pubmed/26844696
http://dx.doi.org/10.1038/cddis.2016.2

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