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cBid, Bax and Bcl-xL exhibit opposite membrane remodeling activities

The proteins of the Bcl-2 family have a crucial role in mitochondrial outer membrane permeabilization during apoptosis and in the regulation of mitochondrial dynamics. Current models consider that Bax forms toroidal pores at mitochondria that are responsible for the release of cytochrome c, whereas...

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Detalles Bibliográficos
Autores principales: Bleicken, S, Hofhaus, G, Ugarte-Uribe, B, Schröder, R, García-Sáez, A J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849160/
https://www.ncbi.nlm.nih.gov/pubmed/26913610
http://dx.doi.org/10.1038/cddis.2016.34