Nicotinamide mononucleotide adenylyltransferase promotes hypoxic survival by activating the mitochondrial unfolded protein response

Gain-of-function mutations in the mouse nicotinamide mononucleotide adenylyltransferase type 1 (Nmnat1) produce two remarkable phenotypes: protection against traumatic axonal degeneration and reduced hypoxic brain injury. Despite intensive efforts, the mechanism of Nmnat1 cytoprotection remains elus...

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Detalles Bibliográficos
Autores principales: Mao, X R, Kaufman, D M, Crowder, C M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849163/
https://www.ncbi.nlm.nih.gov/pubmed/26913604
http://dx.doi.org/10.1038/cddis.2016.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849163/
https://www.ncbi.nlm.nih.gov/pubmed/26913604
http://dx.doi.org/10.1038/cddis.2016.5

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