Hypertension-associated C825T polymorphism impairs the function of Gβ3 to target GRK2 ubiquitination

Population-based and case–control studies in different ethnicities have linked a polymorphism, C825T, in exon 10 of GNB3 gene to hypertension and several additional diseases. The 825T allele is associated with alternative splicing and results in a shortened Gβ3 protein, referred to as Gβ3s, which lo...

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Detalles Bibliográficos
Autores principales: Zha, Zhengyu, Han, Xiao-Ran, Smith, Matthew D, Lei, Qun-Ying, Guan, Kun-Liang, Xiong, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849471/
https://www.ncbi.nlm.nih.gov/pubmed/27462452
http://dx.doi.org/10.1038/celldisc.2016.5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849471/
https://www.ncbi.nlm.nih.gov/pubmed/27462452
http://dx.doi.org/10.1038/celldisc.2016.5

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