Selective Neuromuscular Denervation in Taiwanese Severe SMA Mouse Can Be Reversed by Morpholino Antisense Oligonucleotides

Spinal muscular atrophy (SMA) is an autosomal recessive motor neuron disease caused by deficiency of the survival of motor neuron (SMN) protein, which leads to synaptic defects and spinal motor neuron death. Neuromuscular junction (NMJ) abnormalities have been found to be involved in SMA pathogenesi...

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Detalles Bibliográficos
Autores principales: Lin, Te-Lin, Chen, Tai-Heng, Hsu, Ya-Yun, Cheng, Yu-Hua, Juang, Bi-Tzen, Jong, Yuh-Jyh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849667/
https://www.ncbi.nlm.nih.gov/pubmed/27124114
http://dx.doi.org/10.1371/journal.pone.0154723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849667/
https://www.ncbi.nlm.nih.gov/pubmed/27124114
http://dx.doi.org/10.1371/journal.pone.0154723

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