Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes

During the last decade miltefosine (MIL) has been used as first-line treatment for visceral leishmaniasis in endemic areas with antimonial resistance, but a decline in clinical effectiveness is now being reported. While only two MIL-resistant Leishmania infantum strains from HIV co-infected patients...

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Detalles Bibliográficos
Autores principales: Mondelaers, Annelies, Sanchez-Cañete, Maria P., Hendrickx, Sarah, Eberhardt, Eline, Garcia-Hernandez, Raquel, Lachaud, Laurence, Cotton, James, Sanders, Mandy, Cuypers, Bart, Imamura, Hideo, Dujardin, Jean-Claude, Delputte, Peter, Cos, Paul, Caljon, Guy, Gamarro, Francisco, Castanys, Santiago, Maes, Louis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849676/
https://www.ncbi.nlm.nih.gov/pubmed/27123924
http://dx.doi.org/10.1371/journal.pone.0154101

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849676/
https://www.ncbi.nlm.nih.gov/pubmed/27123924
http://dx.doi.org/10.1371/journal.pone.0154101

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