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Nucleosome Presence at AML-1 Binding Sites Inversely Correlates with Ly49 Expression: Revelations from an Informatics Analysis of Nucleosomes and Immune Cell Transcription Factors

Beyond its role in genomic organization and compaction, the nucleosome is believed to participate in the regulation of gene transcription. Here, we report a computational method to evaluate the nucleosome sensitivity for a transcription factor over a given stretch of the genome. Sensitive factors ar...

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Detalles Bibliográficos
Autores principales: Wight, Andrew, Yang, Doo, Ioshikhes, Ilya, Makrigiannis, Andrew P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849748/
https://www.ncbi.nlm.nih.gov/pubmed/27124577
http://dx.doi.org/10.1371/journal.pcbi.1004894