Rational Structure-Based Rescaffolding Approach to De Novo Design of Interleukin 10 (IL-10) Receptor-1 Mimetics

Tackling protein interfaces with small molecules capable of modulating protein-protein interactions remains a challenge in structure-based ligand design. Particularly arduous are cases in which the epitopes involved in molecular recognition have a non-structured and discontinuous nature. Here, the b...

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Detalles Bibliográficos
Autores principales: Ruiz-Gómez, Gloria, Hawkins, John C., Philipp, Jenny, Künze, Georg, Wodtke, Robert, Löser, Reik, Fahmy, Karim, Pisabarro, M. Teresa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849758/
https://www.ncbi.nlm.nih.gov/pubmed/27123592
http://dx.doi.org/10.1371/journal.pone.0154046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849758/
https://www.ncbi.nlm.nih.gov/pubmed/27123592
http://dx.doi.org/10.1371/journal.pone.0154046

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