The Dynamics of the Human Leukocyte Antigen Head Domain Modulates Its Recognition by the T-Cell Receptor

Generating the immune response requires the discrimination of peptides presented by the human leukocyte antigen complex (HLA) through the T-cell receptor (TCR). However, how a single amino acid substitution in the antigen bonded to HLA affects the response of T cells remains uncertain. Hence, we use...

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Detalles Bibliográficos
Autores principales: García-Guerrero, Estefanía, Pérez-Simón, José Antonio, Sánchez-Abarca, Luis Ignacio, Díaz-Moreno, Irene, De la Rosa, Miguel A., Díaz-Quintana, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849770/
https://www.ncbi.nlm.nih.gov/pubmed/27124285
http://dx.doi.org/10.1371/journal.pone.0154219

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4849770/
https://www.ncbi.nlm.nih.gov/pubmed/27124285
http://dx.doi.org/10.1371/journal.pone.0154219

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