PAR3-aPKC regulates Tiam1 by modulating suppressive internal interactions

Tiam1 is one of the most extensively analyzed activators of the small GTPase Rac. However, fundamental aspects of its regulation are poorly understood. Here we demonstrate that Tiam1 is functionally suppressed by internal interactions and that the PAR complex participates in its full activation. The...

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Detalles Bibliográficos
Autores principales: Matsuzawa, Kenji, Akita, Hiroki, Watanabe, Takashi, Kakeno, Mai, Matsui, Toshinori, Wang, Shujie, Kaibuchi, Kozo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850038/
https://www.ncbi.nlm.nih.gov/pubmed/26941335
http://dx.doi.org/10.1091/mbc.E15-09-0670

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850038/
https://www.ncbi.nlm.nih.gov/pubmed/26941335
http://dx.doi.org/10.1091/mbc.E15-09-0670

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