Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver

Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins—PERK (PEK/EIF2AK3), IRE1, and ATF6—is activated by ER stress. PERK phosphorylation of eIF2 represses global protein synthesis, lo...

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Detalles Bibliográficos
Autores principales: Fusakio, Michael E., Willy, Jeffrey A., Wang, Yongping, Mirek, Emily T., Al Baghdadi, Rana J. T., Adams, Christopher M., Anthony, Tracy G., Wek, Ronald C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850040/
https://www.ncbi.nlm.nih.gov/pubmed/26960794
http://dx.doi.org/10.1091/mbc.E16-01-0039

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850040/
https://www.ncbi.nlm.nih.gov/pubmed/26960794
http://dx.doi.org/10.1091/mbc.E16-01-0039

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