Cargando…
Transcription factor ATF4 directs basal and stress-induced gene expression in the unfolded protein response and cholesterol metabolism in the liver
Disturbances in protein folding and membrane compositions in the endoplasmic reticulum (ER) elicit the unfolded protein response (UPR). Each of three UPR sensory proteins—PERK (PEK/EIF2AK3), IRE1, and ATF6—is activated by ER stress. PERK phosphorylation of eIF2 represses global protein synthesis, lo...
Autores principales: | Fusakio, Michael E., Willy, Jeffrey A., Wang, Yongping, Mirek, Emily T., Al Baghdadi, Rana J. T., Adams, Christopher M., Anthony, Tracy G., Wek, Ronald C. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The American Society for Cell Biology
2016
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4850040/ https://www.ncbi.nlm.nih.gov/pubmed/26960794 http://dx.doi.org/10.1091/mbc.E16-01-0039 |
Ejemplares similares
-
Role of activating transcription factor 4 in the hepatic response to amino acid depletion by asparaginase
por: Al-Baghdadi, Rana J. T., et al.
Publicado: (2017) -
CHOP induces activating transcription factor 5 (ATF5) to trigger apoptosis in response to perturbations in protein homeostasis
por: Teske, Brian F., et al.
Publicado: (2013) -
Activation and execution of the hepatic integrated stress response by dietary essential amino acid deprivation is amino acid specific
por: Jonsson, William O., et al.
Publicado: (2022) -
Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα
por: Baird, Thomas D., et al.
Publicado: (2014) -
The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress
por: Teske, Brian F., et al.
Publicado: (2011)